Human spaceflight has been fascinating man for centuries, representing the intangible need to explore the unknown, challenge new frontiers, advance technology and push scientific boundaries further. A key aspect of long-term human spaceflight is the physiological response and consequent microgravity (0G) adaptation, which has all the features of accelerated aging involving almost every body system: muscle atrophy and bone loss, onset of balance and coordination problems, loss of functional capacity of the cardiovascular system.